Carol Greider: There was a lot of evidence that was already around that there was something going on at the ends of chromosomes, where DNA sequences could be added on to the ends, and that they were dynamic in some manner. There were some competing hypotheses as to how that DNA might be added on to the ends, and there was a very popular competing hypothesis, which was talked about a lot by some famous people who I respected a lot. And that particular thing was a recombination-based model for adding sequences on to the ends of chromosomes. So I do recall feeling a little bit intimidated by the fact that there were some really major groups out there who thought that this same process could be done by a different kind of mechanism. So who was I to think that I could grind up some cells and find some new enzyme that nobody had ever found before? Nevertheless, we thought maybe it’s not done the way they think it’s done. So you come in the lab every day, and do the next experiment, and just keep chugging away like one does a lot of things in life. You just take the next step, and then we found this evidence that the enzyme actually existed.