Frederick Sanger: I think I had a rather sort of — what I’d call lean years between doing the proteins and the nucleic acids. I didn’t get anything very exciting, but it was good enough to keep me going. Fortunately, I didn’t have to sort of, you know, make reports and justify my existence. I think, nowadays, everybody has to put in a report and a proposal of what research you’re going to do, and it does rather limit you, and it sort of points out how little you’ve done. But I did have a period when I didn’t have any papers or anything published. So, I did get a bit discouraged, but once I got onto the nucleic acids and I began to get new and exciting methods, it was getting very exciting again. Ultimately, you see, I managed to develop a method for doing DNA, which is entirely different from the jigsaw puzzle approach that we used with proteins, and is very rapid and simple to do, and this is the method that is being used now for the human genome on a rather large scale, very large, because the human genome is not a smaller thing like insulin. It’s three billion of these residues long, and that’s quite a project.